• C reactive protein is an acute phase protein

  2018-11-12

  

  C-reactive protein is an acute-phase protein produced by hepatocytes on stimulation by IL-6, which indicates a strong correlation between CRP and IL-6. IL-6 production is stimulated by IL-1b. Both IL-1b and IL-6 stimulate the production of IL-1-α, an anti-inflammatory cytokine that antagonizes IL-1

• br Soybeans types of soy

  2018-11-12

  

  Soybeans, types of soy food products and their nutritional functions and consumption Soybean isoflavones: genistein, daidzein, glycitein, and formononetin The association of soy isoflavone food consumption with incidence and prognosis of breast cancer Possible molecular mechanisms of chem

• c-myc inhibitor Vitamin A is toxic in high amounts But

  2018-11-12

  

  Vitamin A is toxic in high amounts. But, the provitamins such as carotene are not toxic. It is reported that doses such as 40,000–50,000 and 25,000 IUs are toxic for adults and children respectively [2]. So, it is recommended to use β-carotene for fortification of dairy products. Health risks begin

• To explain this effect of GAG mimetics on bone regeneration

  2018-11-12

  

  To explain this effect of GAG mimetics on bone regeneration, we hypothesize that it is partly due to their capacity to modulate endogenous MSC properties in vivo. Therefore, to validate this secretin receptor we investigated in this study whether some particular mimetics are able to potentiate effe

• AG-14361 Several pancreatic cancer cell lines and human tiss

  2018-11-12

  

  Several pancreatic cancer cell lines and human tissue samples were surveyed for cell surface, intracellular, and functional markers. CD20, CD24, CD44, CD133, CD184 (CXCR4), CD326 (EpCam), Sox-2, and OCT3/4 were examined in established pancreatic cancer cell lines. The functional marker, i.e., SP, wa

• Although H AZK me could be

  2018-11-12

  

  Although H2AZK7me1 could be detected by ChIP at the transcriptional start site of a few differentiation markers (Fgf5, FoxA2, and Hand2) in E14 mES cells and the level of methylation decreased from those genes in response to retinoic acid-induced differentiation, we still do not know what H2AZK7me1

• br Conclusions This unique technique

  2018-11-12

  

  Conclusions This unique technique developed in rats allows in less than 15min to biopsy olfactory mucosa, without significant impairment in odor discrimination. We show here that olfactory stem cells can be expanded in vitro. It should however be pointed out that the same technique can be used fo

• While M macrophages may be the principal drivers of angiogen

  2018-11-12

  

  While M2 macrophages may be the principal drivers of angiogenesis associated with injury resolution, M1 macrophages are highly fibrolytic, which may facilitate angiogenesis, and secrete pro-angiogenic factors such as TNFα and IL-1β, and nitric oxide (Sunderkotter et al., 1994; Cooke & Losordo, 2002)

• Since the analysis of a complete motor unit

  2018-11-12

  

  Since the analysis of a complete motor unit is essential for the understanding of pathophysiological mechanisms of motoneuron diseases (Moloney et al., 2014), or conditions involving the NMJ, we established an in vitro model of motor units. To that end, we cultivated hiPSC cell lines from healthy co

• SDCs and GPCs have been

  2018-11-12

  

  SDCs and GPCs have been reported to regulate cell adhesion, migration and differentiation and demonstrate specific expression and localisation during CNS development (Choi et al., 2011, Ford-Perriss et al., 2003). The depletion of SDC1, GPC1 and GPC4 in vitro in mouse NSC or neural precursor cells a

• Here we describe the characteristics of a novel SeVdp iPS

  2018-11-09

  

  Here, we describe the characteristics of a novel SeVdp-iPS vector (SeVdp(KOSM)302L) containing miR-302a target sequences at the 3′-UTR of the L gene. This vector can be used for the efficient reprogramming of MEFs into transgene-free iPSCs without the aid of siRNAs, observed using human embryonic fi

• Human liver chimeric mice carrying human pHH can

  2018-11-09

  

  Human liver chimeric mice carrying human pHH can facilitate in vivo study of viral hepatitis infections (Bissig et al., 2010; Carpentier et al., 2014) and liver genetic diseases (Bissig-Choisat et al., 2015; Yusa et al., 2011), and the testing of small molecular drug candidates and biological compon

• Thbs can induce apoptosis via

  2018-11-09

  

  Thbs1 can induce apoptosis via upregulation of active caspase-3 (Li et al., 2003). Consistently, Lxn−/− HSCs demonstrated decreased apoptosis and reduced levels of active caspase-3, suggesting that downregulation of Thbs1 might also intrinsically enhance Lxn−/− stem cell survival (Figure 7G). An inc

• pitavastatin While the results of the

  2018-11-09

  

  While the results of the membrane-based γ-secretase assays are not consistent with a direct effect on the core γ-secretase complex, there are indirect ways by which APP proteolysis may be altered that could go undetected in a cell-free assay. The specific APP processing paths leading to the generati

• Specific transcriptional networks play an essential role in

  2018-11-09

  

  Specific transcriptional networks play an essential role in sustaining the growth and self-renewal of embryonic stem order Chloroquine (ESCs) and neoplastic stem-like cells. Expression of a defined and limited set of transcription factors (i.e., SOX2, OCT3/4, NANOG, KLF4, C-MYC, and BMI1) can repro

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